Product Name	MTLC
Chinese Name	致癌基因抗体
Alias	myc target 1; Myc target 1; MYCT 1 protein; Myc target in myeloid cells protein 1; Myc target protein 1; 1110020B04Rik; AI225941; AI642973; FLJ21269; MGC156309; MGC156310; Mt-Mc1; MTLC; Mtmc1; MYCT1; MYCT1_HUMAN; Myct1; MTMC1.
literatures	Specific References  (2)     |     SL0334R has been referenced in 2 publications. [IF=3.487] Zhang C et al. MiR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway.Cell Signal. 2018 Oct;50:80-89.  WB ;  Rat.   PubMed:29958992 [IF=3.414] Li Y et al. Yin Yang Gong Ji pill is an ancient formula with antitumor activity against hepatoma cells J Ethnopharmacol. 2019 Oct 3;248:112267.  WB ;  Human&Mouse.   PubMed:31586691
Research Area	immunology  Chromatin and nuclear signals  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MTLC: 21-100/235
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MTLC is a 235 amino acid nuclear protein that is thought to regulate certain myc target genes. Downregulated in gastric cancer tissues, MTLC is expressed in the hepatocellular carcinoma cell line, Bel7402. Overexpression of MTLC is thought to influence tumorigenic conversion, promotion of apoptosis genomic instability and inhibition of hematopoietic differentiation. The gene encoding MTLC maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. Function: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. Subcellular Location: Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line Bel7402 cells. Tissue Specificity: Down-regulated in gastric cancer tissues. Similarity: Belongs to the MYCT1 family. SWISS: Q8N699 Gene ID: 80177 Database links: Entrez Gene: 80177 Human Entrez Gene: 68632 Mouse Entrez Gene: 292264 Rat SwissProt: Q8N699 Human SwissProt: Q8R411 Mouse Unigene: 18160 Human Unigene: 338242 Mouse Unigene: 55418 Rat transcriptional regulatory factor（Transcriptin Regulators）
Product Picture	Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti- MTLC (SL0334R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 27 kD Observed band size: 31 kD Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-MTLC Polyclonal Antibody, Unconjugated(SL0334R) 1:200, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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