Product Name	PACAP-27/38
Chinese Name	腺苷酸环化酶激活肽-27/38抗体
Alias	Adenylate Cyclase Activating Polypeptide 1 (Pituitary); Prepro-PACAP; PACAP; Pituitary Adenylate Cyclase Activating Polypeptide; PRP-48; PACAP27; PACAP38; ADCYAP1; PACA_HUMAN;   Pituitary Adenylate Cyclase-Activating Polypeptide; Adenylate Cyclase Activating Polypeptide 1; PRP48; PACAP-27; PACAP-38;
literatures	Specific References  (4)     |     SL0190R has been referenced in 4 publications. [IF=8.739] Hailou Zhang. et al. Synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal PACAP signaling. 2022 Mar 31  WB,IF ;  Mouse.   PubMed:35362097 [IF=4.755] Han Xuke. et al. Effects of electroacupuncture on bladder dysfunction and the expression of PACAP38 in a diabetic rat model. FRONT PHYSIOL. 2022 Dec;13:2751  WB ;  Rat.   PubMed:36699677 [IF=3.188] Zeqi Tang. et al. Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus). EUR J HISTOCHEM. 2022 Mar 24; 66(2): 3398  IHC ;  Rat.   PubMed:35502591 [IF=2.276] Lu L et al. Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide. Biomed Res Int. 2020 Jun 24;2020:3903125.  WB ;  Rat.   PubMed:32685478
Research Area	Cell biology  Neurobiology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PACAP-27/38: 132-169/176
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. Subunit: Interacts with ADCYAP1R1 (via N-terminal extracellular domain). Subcellular Location: Extracellular region or secreted Similarity: Belongs to the glucagon family. SWISS: P18509 Gene ID: 116 Database links: Entrez Gene: 116 Human Entrez Gene: 11516 Mouse Entrez Gene: 414283 Pig Entrez Gene: 24166 Rat Omim: 102980 Human SwissProt: P18509 Human SwissProt: O70176 Mouse SwissProt: P41535 Pig SwissProt: P13589 Rat Unigene: 531719 Human Unigene: 727476 Human Unigene: 3407 Mouse Unigene: 37400 Rat 腺苷酸环化酶激活肽是一种可激活垂体腺苷酸环化酶的多肽，有PACAP-27和 PACAP-38两种形式，他们共同具有N端27个氨基酸，属于PACAP/glucagon超级家族。在中枢神经系统分布广泛，其中以下丘脑含量最高。
Product Picture	Sample: Cerebrum (Rat) Lysate at 40 ug Primary: Anti- PACAP-27/38 (SL0190R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 19 kD Observed band size: 20 kD

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