Product Name	Neuropeptide Y
Chinese Name	神经肽Y抗体
Alias	Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; Pro-neuropeptide Y; NPY_HUMAN.
literatures	Specific References  (5)     |     SL0071R has been referenced in 5 publications. [IF=4.546] Quancheng Liu. et al. FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs. Toxins. 2021 Dec;13(12):874  WB,IHC ;  Pig.   PubMed:34941712 [IF=3.23] Chen, Guiqian, et al. "The Stimulatory Effect of Cerebral Intraventricular Injection of cNPY on Precocial Feeding Behavior in Neonatal Chicks (Gallus domesticus)." PloS one 11.4 (2016): e0153342.  other ;  Chicken.   PubMed:27055273 [IF=2.23] Dong et al. Anti-epileptic effects of neuropeptide Y gene transfection into the rat brain. (2013) Neural.Regen.Res. 8:1307-15  WB ;  Rat.   PubMed:25206425 [IF=2.02] Duan, Hubin, et al. "The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury." Journal of Surgical Research (2013).  IHC-P ;  Rat.   PubMed:23622727 [IF=1.89] Chen, Shengru, et al. "Changes in nerve fibers and microvessel density in residual spleen after subtotal splenectomy due to portal hypertension." International Journal of Clinical and Experimental Pathology 9.2 (2016): 1557-1567.  IHC-P ;  Human.   PubMed:ISSN:1936-2625/IJCEP0018875
Research Area	Cardiovascular  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4/8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NPY: 29-64/97
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Subcellular Location: Secreted. Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. Post-translational modifications: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Similarity: Belongs to the NPY family. SWISS: P01303 Gene ID: 4852 Database links: Entrez Gene: 396464 Chicken Entrez Gene: 504216 Cow Entrez Gene: 4852 Human Entrez Gene: 109648 Mouse Entrez Gene: 397304 Pig Entrez Gene: 24604 Rat Omim: 162640 Human Neurobiology相关蛋白 神经肽Y是一种神经传导因子，参与机体的应急反应， 在应激状态下-NPY升高;他还可以促进血小板聚集、白细胞粘附及 巨噬细胞活化而参 与免疫反应 神经肽Y广泛分布于动物中枢和外周神经元及机体组织、器官和腺体内 ,影响动物采食、激素分泌、Cardiovascular效应、调节体温、生物节律、性行为及动物情绪等多种功能。 由于结构中富含酪氨酸 ,故称为神经肽酪氨酸 (NPY)。它的结构与同是 36个氨基酸的胰多肽 (pp)和肽 YY(PYY)极其相似 ,故认为同属胰多肽家族。从分子结构看 ,人、大鼠、豚鼠和兔序列安全一致 ,而牛、羊、猪 NPY序列与人的序列只相差一个氨基酸。
Product Picture	Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-NPY/Neuropeptide Y Polyclonal Antibody, Unconjugated(SL0071R) 1:400, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining Paraformaldehyde-fixed, paraffin embedded (Rat adrenal gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Neuropeptide Y) Polyclonal Antibody, Unconjugated (SL0071R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Formalin-fixed and paraffin-embedded rat brain tissue labeled with Rabbit Anti-NPY/Neuropeptide Y Polyclonal Antibody, Unconjugated(SL0071R) at 1:400 followed byconjugation to the secondary antibody and DAB staining

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