Product Name	NGFB
Chinese Name	神经生长因子β抗体
Alias	NGF; Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN.  NGF-β; NGF β; NGFβ; β NGF; β-NGF; .
literatures	Specific References  (10)     |     SL0067R has been referenced in 10 publications. [IF=12.416] Zhou, Zhen. et al. Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. BASIC RES CARDIOL. 2022 Dec;117(1):1-17  WB ;  Dog.   PubMed:35819552 [IF=4.94] Li, Hui, et al. "Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta." Journal of cellular and molecular medicine 16.7 (2012): 1606-1617.  IHC-P ;  Rat.   PubMed:22004004 [IF=3.85] Zhang, Jianhai, et al. "Choline supplementation alleviates fluoride-induced testicular toxicity by restoring the NGF and MEK expression in mice."Toxicology and Applied Pharmacology 310 (2016): 205-214.  IHC-P ;  Mouse.   PubMed:27664006 [IF=3.244] Fu XM et al. The Combination of Adipose-derived Schwann-like Cells and Acellular Nerve Allografts PromotesSciatic Nerve Regeneration and Repair through the JAK2/STAT3 Signaling Pathway in Rats. Neuroscience. 2019 Nov 1;422:134-145.  ICF&WB ;  Rat.   PubMed:31682951 [IF=2.833] Chengjie Wu. et al. Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress. Bmc Complem Altern M. 2021 Dec;21(1):1-8  other ;   PubMed:33607999 [IF=2.784] Luo BB et al. Connexin 43 reduces susceptibility to sympathetic atrial fibrillation. INTERNATIONAL JOURNAL OF MOlecular medici. 2018,42(2):1125-1133.  IHC-P ;  Dog.   PubMed:DOI:10.3892/ijmm.2018.3648 [IF=2.46] Lu, Yanmei, et al. "Effect of Low-level Vagus Nerve Stimulation on Cardiac Remodeling in a Rapid Atrial Pacing–induced Canine Model of Atrial Fibrillation." Journal of cardiovascular pharmacology 67.3 (2016): 218-224.  IHC-P ;  Dog.   PubMed:26727379 [IF=2.05] Neupane S et al.Focal localization of inflammatory cytokines and neurotrophins in a tongue chronic injury model. (2019) Archives of Oral Biology 99, 22–30.  IHC-P ;  Mouse.   PubMed:30590230 [IF=1.19] Shu et al. Connexin 43 is involved in the sympathetic atrial fibrillation in canine and canine atrial myocytes. (2017) Anatol.J.Cardiol. 18:3-9  IHC ;  Canine.   PubMed:28554986 [IF=1.13] Li, Xiaoming, et al. "Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma." Acta oto-laryngologica 132.3 (2012): 314-324.  IHC-P ;  Human.   PubMed:22201277
Research Area	Developmental biology  Neurobiology  cell factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat, Dog,  (predicted: Mouse, Chicken, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13/32kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NGF beta: 151-220/241
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Subunit: Homodimer. Subcellular Location: Secreted. DISEASE: Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. Similarity: Belongs to the NGF-beta family. SWISS: P01138 Gene ID: 4803 Database links: Entrez Gene: 4803 Human Entrez Gene: 18049 Mouse Entrez Gene: 310738 Rat Omim: 162030 Human SwissProt: P01138 Human SwissProt: P01139 Mouse SwissProt: P25427 Rat Unigene: 2561 Human Unigene: 1259 Mouse Unigene: 22168 Rat 神经生长因子-β(NGF-β)属于一种对神经元的生长、分化、延长存活期有促进作用的神经生长因子家族。此抗体识别分子量为29kDa 的NGF蛋白。 神经生长因子(Nerve Growth Factor,NGF)是最早被发现、兼有神经元营养和促突触生长双重生物学功能的一种细胞调节因子.它对中枢和周围神经元的发育、分化、生长、再生和功能特性的表达均具有重要的调控作用,可促进受损神经再生、免受继发性损害、减少细胞死亡、支持神经元存活等功能.
Product Picture	Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NGF-beta Polyclonal Antibody, Unconjugated(SL0067R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining SH-SY5Y cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (NGFB) polyclonal Antibody, Unconjugated (SL0067R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

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