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Product Name Anti-Gastrin Releasing Peptide/RBITC Chinese Name 罗丹明(RBITC)标记的促胃泌素释放肽抗体 Alias Gastrin releasing peptides; BN; Bombesin; GRP 10; GRP; GRP10; Neuromedin C; NeuromedinC; Pre progastrin releasing peptide; preproGRP; proGRP; GRP_HUMAN. Research Area Tumour Neurobiology Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 3kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GRP Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function:
GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus.
Similarity:
Belongs to the bombesin/neuromedin-B/ranatensin family.
Database links:Entrez Gene: 2922 Human
Entrez Gene: 225642 Mouse
Omim: 137260 Human
SwissProt: P07492 Human
SwissProt: Q8R1I2 Mouse
Unigene: 153444 Human
Unigene: 20298 Mouse
Unigene: 10930 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GRP广泛分布于神经系统、胃肠道以及正常肺组织中,是神经内分泌激素。在多种Tumour中以自分泌方式分泌。能调节表皮生长因子,具有多种生物活性。
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