Product Name	Anti-TIMP-3/RBITC
Chinese Name	罗丹明（RBITC）标记的金属蛋白酶组织抑制因子-3抗体
Alias	HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN.
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  Apoptosis  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	21kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TIMP-3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. Subunit: Interacts with EFEMP1. Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. Database links: Entrez Gene: 7078 Human Entrez Gene: 21859 Mouse Entrez Gene: 25358 Rat Omim: 188826 Human SwissProt: P35625 Human SwissProt: P39876 Mouse SwissProt: P48032 Rat Unigene: 644633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Synthesis and Degradation（Synthesis and Degradation） 近年来，国内外科研人员对TIMP-3的抗Tumour作用日益被重视，学者认为：TIMP-3具有强烈促凋亡、抑制血管生成、抗Tumour浸润作用，TIMP-3与TIMP-1、2且相互间有明显协同抗Tumour作用

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