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Product Name Anti-TSLP/RBITC Chinese Name 罗丹明(RBITC)标记的胸腺基质lymphocyte生成素-1抗体 Alias Thymic stromal lymphopoietin isoform 1; Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; TSLP protein; TSLP_HUMAN. Research Area Cell biology immunology cell factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 15kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TSP-1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ-3. Anti-interleukin (IL)-7 receptor antibodies (Abs) neutralized this effect indicating that TSLP binds to at least part of the IL-7 receptor complex. TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5.
Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Subunit:
Interacts with a receptor composed of CRLF2 and IL7R.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in a number of tissues including heart, liver and prostate.
Database links:Entrez Gene: 85480 Human
Entrez Gene: 53603 Mouse
Omim: 607003 Human
SwissProt: Q969D9 Human
SwissProt: Q9JIE6 Mouse
Unigene: 389874 Human
Unigene: 143716 Mouse
Unigene: 201724 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胸腺基质lymphocyte生成素-1(胸腺基质细胞分泌的lymphocyte生成素-1)
为一种新型促进生长的cell factor——胸腺基质淋巴蛋白(TSLP)可以引发炎症反应, 这种炎症反应可以引起很多过敏性疾病和哮喘。
TSLP可能是过敏性疾病最重要的引发剂,已得到科学家的重视,如果证实了 TSLP是一种起始因子,抑制TSLP可以有效地治疗哮喘和其它过敏性疾病。
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