Product Name	Anti-Plexin A1/RBITC
Chinese Name	罗丹明（RBITC）标记的神经丛蛋白A1抗体
Alias	NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV; PLXA1_HUMAN.
Research Area	Cardiovascular  Cell biology  immunology  Developmental biology  Neurobiology  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	206kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Plexin A1 (926-974aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury. Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Subunit: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Subcellular Location: Cell membrane (Probable); Single-pass type I membrane protein. Tissue Specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. Database links: Entrez Gene: 5361 Human Entrez Gene: 18844 Mouse NCBI: NP_115618 Human Omim: 601055 Human SwissProt: Q9UIW2 Human SwissProt: P70206 Mouse Unigene: 432329 Human Unigene: 549421 Human Unigene: 3789 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Plexins是一种单途径、具有多向潜在功能的Transmembrane protein，为Sema-phorins（神经信号蛋白）家族的受体,PlexinA1蛋白主要定位于细胞质和The cell membrane，Semaphorins的很多重要的生理作用均是通过Plexins信号传导来发挥作用的。PlexinA1在神经系统形成、Cardiovascular生成、胚胎发生和免疫反应等方面发挥重要作用。

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