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Product Name Anti-Fetuin A/AHSG/RBITC Chinese Name 罗丹明(RBITC)标记的胎球蛋白A Alias Fetuin-A; 59 kDa bone sialic acid containing protein; A2HS; Aa2 066; AHS; AHSG; Alpha 2 HS glycoprotein; Alpha 2 HS glycoprotein chain A; Alpha 2 Z globulin; Alpha 2HS glycoprotein; alpha2 Heremans Schmid glycoprotein; Asialofetuin; Ba alpha 2 glycoprotein; BSP; Countertrypin; FETUA; Fetuin A; Fetuin, mouse, homolog of ; FetuinA; Glycoprotein PP63; HSGA; pp63; Alpha-2-HS-glycoprotein chain A Research Area immunology Neurobiology Signal transduction Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 31/40kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Alpha-2-HS-glycoprotein chain A. Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
Function:
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Subunit:
Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.
Subcellular Location:
Secreted.
Tissue Specificity:
Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
Similarity:
Belongs to the fetuin family.
Contains 2 cystatin fetuin-A-type domains.
Database links:Entrez Gene: 197 Human
Entrez Gene: 26998 Human
Omim: 138680 Human
Omim: 605954 Human
SwissProt: P02765 Human
SwissProt: Q9UGM5 Human
Unigene: 324746 Human
Unigene: 81073 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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