Product Name	Anti-SKALP/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的弹性蛋白酶抑制剂抗体
Alias	ELAF_HUMAN; Elafin; Elastase Specific Inhibitor; Elastase-specific inhibitor; ES 1; ESI; Peptidase inhibitor 3; PI 3; PI-3; PI3; Protease inhibitor 3 skin derived; Protease inhibitor WAP3; SKALP; Skin derived Anti leukoproteinase; Skin-derived antileukoproteinase; Trappin 2; WAP four disulfide core domain protein 14; WAP four-disulfide core domain protein 14; WFDC14.
Research Area	Tumour  Cell biology  immunology  Signal transduction  Bacteria and viruses  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	13kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SKALP/Elafin
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008] Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Subcellular Location: Secreted. Similarity: Contains 1 WAP domain. Database links: Entrez Gene: 5266 Human Omim: 182257 Human SwissProt: P19957 Human Unigene: 112341 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Elafin,又称SKALP(Skin-derived antileucoproteinase)或弹性蛋白酶特异性抑制剂(Elastase-Specific Inhibitor,ESI),它是一种低分子量的弹性蛋白酶抑制剂。它属于“trappin”蛋白家族Trappin-2,具有拮抗胰弹性蛋白酶、中性粒细胞弹性蛋白酶(NE)和蛋白酶3的作用。

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