Product Name	Anti-FGF8/PE-Cy3
Chinese Name	PE-Cy3标记的成纤维细胞生长因子8抗体
Alias	AIGF; Androgen induced growth factor; Androgen-induced growth factor; FGF 8; FGF-8; FGF8; Fibroblast growth factor 8 (androgen induced); Fibroblast growth factor 8 precursor; HBGF 8; HBGF-8; HBGF8; FGF8_HUMAN.
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	27kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FGF8
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Keratinocyte growth factor precursor (KGF) (Fibroblast growth factor 8; FGF-8; HBGF-8). Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. [Subcellular location] Secreted. [Tissue specificity] Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos. [Induction] By androgens. Belongs to the heparin-binding growth factors family. Function: Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Subcellular Location: Secreted. DISEASE: Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Similarity: Belongs to the heparin-binding growth factors family. Database links: Entrez Gene: 2253 Human Entrez Gene: 14179 Mouse Entrez Gene: 29349 Rat Omim: 600483 Human SwissProt: P55075 Human SwissProt: P37237 Mouse Unigene: 57710 Human Unigene: 4012 Mouse Unigene: 73565 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有研究者认为：纤维母细胞生长因子8 FGF8 对癌症具有一定的抑制作用。 早期研究FGF8，认为是自分泌生长因子，它在前列腺癌、乳癌和卵巢癌中常常表现过量表达 (over-expressed)，并与前列腺癌的格里森分数 (Gleason score) 相关联。经过各种细胞和动物模型的实验均支持FGF8在抑制Tumour形成和Tumour细胞成活方面的作用。 此外，还有学者认为：FGF8 还在实验中显示出，他有改善因Collagen protein引发的关节炎性的改变，如：风湿性关节炎和类风湿性关节炎及退行性骨性关节病。

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