Product Name	Anti-KPI2/HRP
Chinese Name	辣根过氧化物酶标记的丝氨酸/苏氨酸蛋白激酶KPI2抗体
Alias	AATYK 2; AATYK2; Apoptosis associated tyrosine kinase 2; Apoptosis-associated tyrosine kinase 2; Brain enriched kinase; Brain-enriched kinase; BREK; CDK5/p35 regulated kinase; CDK5/p35-regulated kinase; CPRK; cyclin-dependent kinase 5/p35-regulated kinase; FLJ46659; hBREK; KIAA1079; Kinase phosphatase inhibitor 2; Kinase/phosphatase/inhibitor 2; KPI 2; KPI-2; Lemur tyrosine kinase 2; LMR 2; LMR2; LMTK 2; Lmtk2; LMTK2_HUMAN; Serine/threonine protein kinase KPI 2; Serine/threonine protein kinase KPI2; Serine/threonine protein kinase LMTK 2; Serine/threonine protein kinase LMTK2; Serine/threonine-protein kinase KPI-2; Serine/threonine-protein kinase LMTK2.
Research Area	Cell biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	164kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KPI2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] Function: Phosphorylates PPP1C, phosphorylase b and CFTR. Subcellular Location: Membrane. Tissue Specificity: Mainly expressed in skeletal muscle, and weakly in brain and pancreas. Post-translational modifications: Autophosphorylated. Phosphorylated. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain. Database links: Entrez Gene: 22853 Human Omim: 610989 Human SwissProt: Q8IWU2 Human Unigene: 444179 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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