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Product Name Anti-CRHBP/HRP Chinese Name 辣根过氧化物酶标记的促肾上腺皮质激素释放激素Binding protein抗体 Alias CRH-BP; Corticotropin releasing hormone binding protein; CRF binding protein; CRF BP; CRH BP; Corticotropin releasing factor binding protein; CRFBP; Research Area Cardiovascular Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 33kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CRHBP Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
CRHBP is a potent stimulator of synthesis and secretion of preopiomelanocortin derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH binding protein which inactivates CRH and which may prevent inappropriate pituitary adrenal stimulation in pregnancy.
Function:
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Subcellular Location:
Secreted.
Similarity:
Belongs to the CRF-binding protein family.
Database links:Entrez Gene: 1393 Human
Omim: 122559 Human
SwissProt: P24387 Human
Unigene: 115617 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Product Picture
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