Product Name	Anti-Dermatopontin/Gold
Chinese Name	胶体金标记的皮肤桥蛋白抗体
Alias	DERM_HUMAN; Dermatopontin; Dpt; TRAMP; Tyrosine rich acidic matrix protein; Tyrosine-rich acidic matrix protein.
Research Area	Signal transduction  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
Applications	IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	24kDa
Form	Lyophilized or Liquid
Concentration	0.4mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Dermatopontin
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
Storage	Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
Product Detail	background: Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008] Function: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Subcellular Location: Secreted > extracellular space > extracellular matrix. Tissue Specificity: Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. Post-translational modifications: Sulfated on tyrosine residue(s). Similarity: Belongs to the dermatopontin family. Database links: Entrez Gene: 1805 Human Omim: 125597 Human SwissProt: Q07507 Human Unigene: 80552 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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