Product Name	Anti-LY6D/Cy7
Chinese Name	Cy7标记的lymphocyte抗原Ly6D抗体
Alias	E48 antigen; LY 6D; LY-6D;Lymphocyte antigen 6 complex; LY6D_HUMAN; Lymphocyte antigen 6 complex locus D; Lymphocyte antigen D; Lymphocyte antigen 6D.
Research Area	Cell biology  immunology  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	8.4kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LY6D
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Product Detail	background: Ly-6D is a 128 amino acid glycoprotein that is expressed in squamous cell carcinoma cell lines and squamous cell epithelia tissue. Ly-6D contains a signal peptide, 2 theoretical phosphorylation sites and 3 putative myristoylation sites. Upregulation of the gene encoding Ly-6D in head and neck cancers is associated with poor prognosis and high expression of Ly-6D has been linked to enhanced cell migration. Ly-6D is frequently used as a molecular marker for diagnosis and therapy of head-and-neck squamous cell carcinoma (HNSCC). It has been suggested that Ly-6D may regulate the expression levels of certain fucosylated E-selectin ligands and protein FX, a protein that contributes to the last step in the synthesis of GDP-L-fucose, in HNSCC cell lines. This finding is indicative that Ly-6D may regulate tumor cell adhesion in inflamed vessel walls that express E-selectin. Function: May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. Subcellular Location: Cell membrane; Lipid-anchor ?GPI-anchor Tissue Specificity: Expressed exclusively at the outer cell surface of transitional epithelia and the keratinocyte of stratified squamous epithelia. Similarity: Contains 1 UPAR/Ly6 domain. Database links:   http://www.ncbi.nlm.nih.gov/protein/2501524 UniProtKB/Swiss-Prot: Q14210.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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