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Product Name Anti-TNS4/Cy7 Chinese Name Cy7标记的张力蛋白4抗体 Alias C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4. Research Area Tumour Cell biology Signal transduction Cell adhesion molecule Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 75kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNS4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a role in tumor suppression
Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
Subcellular Location:
Cell junction > focal adhesion. Cytoplasm > cytoskeleton.
Tissue Specificity:
Prostate and placenta. Down regulated in prostate cancer.
Post-translational modifications:
Proteolytically cleaved by caspase-3 during apoptosis.
Similarity:
Contains 1 phosphatase tensin-type domain.
Contains 1 SH2 domain.
Database links:Entrez Gene: 84951 Human
Entrez Gene: 217169 Mouse
Omim: 608385 Human
SwissProt: Q8IZW8 Human
SwissProt: Q8BZ33 Mouse
Unigene: 438292 Human
Unigene: 262067 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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