Product Name	Anti-LARP7/Cy7
Chinese Name	Cy7标记的LARP7蛋白抗体
Alias	DKFZp564K112; HDCMA18P; La related protein 7; La ribonucleoprotein domain family member 7; La ribonucleoprotein domain family member 7; La-related protein 7; LARP 7; larp7; LARP7_HUMAN; MGC104360; P TEFb interaction protein for 7SK stability; P-TEFb-interaction protein for 7SK stability; PIP7S.
Research Area	Cell biology  transcriptional regulatory factor  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	67kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LARP7
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Subcellular Location: Nucleus > nucleoplasm. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 51574 Human Entrez Gene: 28036 Mouse Entrez Gene: 686883 Rat Omim: 612026 Human SwissProt: Q4G0J3 Human SwissProt: Q05CL8 Mouse SwissProt: Q5XI01 Rat Unigene: 713663 Human Unigene: 291032 Mouse Unigene: 168323 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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