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Product Name Anti-CCL26/Cy5.5 Chinese Name Cy5.5标记的Chemokine26/嗜酸粒细胞趋化蛋白3抗体 Alias C-C motif chemokine 26; CC chemokine IMAC; CCL 26; CCL26; Chemokine (C C motif) ligand 26; Eotaxin-3; IMAC; Macrophage inflammatory protein 4-alpha; MIP 4a; MIP 4alpha; MIP-4-alpha; MIP4a; MIP4alpha; SCYA 26; SCYA26; Small inducible cytokine A26; Small inducible cytokine subfamily A (Cys Cys) member 26; Small inducible cytokine subfamily A member 26; Small-inducible cytokine A26; Thymic stroma chemokine 1; Thymic stroma chemokine-1; TSC 1; TSC-1; TSC1. Research Area Cell biology immunology Apoptosis Chemokine Ubiquitin Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 8kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rat CCL26 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
Function:
Chemotactic for eosinophils and basophils. Binds to CCR3.
Subunit:
Monomer.
Subcellular Location:
Secreted.
Tissue Specificity:
Ubiquitously expressed at low levels in various tissues including heart and ovary.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:Entrez Gene: 10344 Human
Entrez Gene: 541307 Mouse
Omim: 604697 Human
SwissProt: Q9Y258 Human
Unigene: 131342 Human
Unigene: 376459 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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