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Rabbit Anti-EP3/PTGER3/Cy5.5 Conjugated antibody
Rabbit Anti-EP3/PTGER3/Cy5.5 Conjugated antibody
EP 3; EP3; EP3 I; EP3 II; EP3 III; EP3 IV; Ep3 prostanoid receptor; Ep3 receptor; EP3 subtype; EP3e; HGNC:9595; MGC141828; MGC141829; MGC27302; PE2R3_HUMAN; PGE receptor EP3 subtype; PGE2 R; PGE2 receptor EP3 subtype; PGE2-R; PGE2R; Pgerep3; Prostaglandin
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Details

Product Name Anti-EP3/PTGER3/Cy5.5
Chinese Name Cy5.5标记的前列腺素E受体3抗体
Alias EP 3; EP3; EP3 I; EP3 II; EP3 III; EP3 IV; Ep3 prostanoid receptor; Ep3 receptor; EP3 subtype; EP3e; HGNC:9595; MGC141828; MGC141829; MGC27302; PE2R3_HUMAN; PGE receptor EP3 subtype; PGE2 R; PGE2 receptor EP3 subtype; PGE2-R; PGE2R; Pgerep3; Prostaglandin E receptor 3 (subtype EP3); Prostaglandin E receptor 3; Prostaglandin E receptor EP3 subtype 3 isoform; Prostaglandin E2 receptor; Prostaglandin e2 receptor ep3; Prostaglandin E2 receptor EP3 subtype; Prostaglandin receptor (PGE 2); Prostaglandin receptor 3, EP3, subtype; Prostanoid EP3 receptor; PTGER 3; Ptger3; Ptgerep3; Rep3; rEP3a; rEP3b.  
Research Area Signal transduction  G protein-coupled receptor  The new supersedes the old  G protein signal  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Pig, Horse, Rabbit, )
Applications Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 43kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human EP3
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 5733 Human

Entrez Gene: 19218 Mouse

Entrez Gene: 24929 Rat

Omim: 176806 Human

SwissProt: P43115 Human

SwissProt: P30557 Mouse

SwissProt: P34980 Rat

Unigene: 445000 Human

Unigene: 30424 Mouse

Unigene: 10361 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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