Product Name	Anti-CD2/Cy5.5
Chinese Name	Cy5.5标记的CD2抗体
Alias	T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11/Leu 5; T11; CD2_HUMAN.
Research Area	Cell biology  immunology  Stem cells  Cell Surface Molecule  glycoprotein  Natural killer cells  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Horse, )
Applications	Flow-Cyt=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	37kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Subunit: Interacts with CD2AP. Interacts with PSTPIP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 914 Human Entrez Gene: 12481 Mouse Entrez Gene: 497761 Rat Omim: 186990 Human SwissProt: P06729 Human SwissProt: P08920 Mouse SwissProt: P08921 Rat Unigene: 523500 Human Unigene: 22842 Mouse Unigene: 10328 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD2分子又称T11、绵羊红细胞受体（ER）、lymphocyte功能相关抗原2（LFA-2）和Leu5，是人Tlymphocyte表面的单链glycoprotein.CD2分子是分布于胸腺细胞及所有成熟Tlymphocyte和大部分Natural killer cells表面的特征性分化抗原。CD2具有调节Tlymphocyte分化、成熟、激活和凋亡等功能，CD2与LFA-3之间的粘附功能对于TlymphocyteTCR识别外来抗原与APC细胞表面MHC抗原复合物、Tumour抗原、病毒感染靶细胞以及同种异体抗原均有重要的辅助作用。 最近研究表明，CD48和CD59也是CD2的配体，参与T细胞的粘附和细胞间的相互作用,此外，CD2可以与其它膜分子如CD44、CD45的功能有关。CD2具有对T细胞的旁路激活途径作用。

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