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Product Name Anti-Kinesin C2/Cy3 Chinese Name Cy3标记的驱动蛋白家族成员C2抗体 Alias KIF C2; KIFC 2; KIFC2; KIFC2 protein; KIFC2_HUMAN; Kinesin family member C2; Kinesin like protein KIFC2; Kinesin-like protein KIFC2. Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Cow, Horse, Sheep, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 90kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Kinesin C2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. Cells use KIFs to tightly control the direction, destination, and speed of transportation of a variety of important functional molecules, including mRNA. KIFC2 is 792 amino acid member of the C-terminal motor family specifically expressed in both the central and peripheral nervous systems in nonproliferative cells. KIFC2 accumulates at the proximal and distal sides of axons and is a minus-end-directed kinesin. KIFC2 localizes with some, but not all, axonally transported organelles. KIFC2 may be involved in retrograde axonal transport.
Function:
May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites.
Subcellular Location:
Cytoplasm; cytoskeleton.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
Database links:Entrez Gene: 90990 Human
Entrez Gene: 16581 Mouse
SwissProt: Q96AC6 Human
SwissProt: O08672 Mouse
Unigene: 528713 Human
Unigene: 378950 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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