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Product Name Anti-CD27/Biotin Chinese Name 生物素标记的CD27抗体 Alias CD 27; Cd27; CD27 antigen; CD27 molecule; CD27_MOUSE; CD27L receptor; LPFS2; MGC20393; OTTHUMP00000238557; S152; T cell activation antigen CD27; T cell antivation antigen S152; T-cell activation antigen CD27; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; Tumor necrosis factor receptor superfamily member 7. Research Area Tumour immunology Stem cells lymphocyte t-lymphocyte cell factor Immunogen Species Rabbit Clonality Polyclonal React Species Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 27kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD27 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Function:
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Subunit:
Homodimer. Interacts with SIVA1 and TRAF2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Found in most T-lymphocytes.
Post-translational modifications:
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Similarity:
Contains 3 TNFR-Cys repeats.
Database links:Entrez Gene: 939 Human
Entrez Gene: 21940 Mouse
Omim: 186711 Human
SwissProt: P26842 Human
SwissProt: P41272 Mouse
Unigene: 355307 Human
Unigene: 367714 Mouse
Unigene: 134200 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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