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Product Name Anti-Hrasls3/Biotin Chinese Name 生物素标记的HRAS样抑制因子3抗体 Alias H rev 107 protein homolog; HRAS like suppressor 3; HREV107 3; HREV107; Renal carcinoma antigen NY REN 65; Adipose specific phospholipase A2; Group XVI phospholipase A2; HREV107; HRSL3_MOUSE; AdPLA; HRSL3; HRASLS3; HREV107-1; HREV107-3; H-REV107-1. Research Area immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 18kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Hrasls3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
HRASLS3 specifically catalyzes the release of fatty acids from phospholipids in adipose tissue and also has a weak lysophospholipase activity. It is a tumor suppressor that may be involved in interferon-dependent cell death.
Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N-and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity.
Subunit:
Interacts with PPP2R1A; this interaction might decrease PP2A activity.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential). Cytoplasm. Cytoplasm, perinuclear region.
Tissue Specificity:
Ubiquitously expressed in normal tissues but down-regulated in primary carcinomas or in many cell lines derived from tumors. Highly expressed in white adipose tissue and in adipocytes. Expressed at lower levels in brown adipose tissue.
Similarity:
Belongs to the H-rev107 family.
Database links:Entrez Gene: 11145 Human
Entrez Gene: 225845 Mouse
Omim: 613867 Human
SwissProt: P53816 Human
SwissProt: Q8R3U1 Mouse
Unigene: 502775 Human
Unigene: 274810 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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