TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-RANBP17/Biotin Chinese Name 生物素标记的RANBinding protein17抗体 Alias Exp 7; Exp7; Exportin 7; Exportin7; KIAA0745; RAN binding protein 16; RANBP 16; XPO 7; XPO7. Research Area Cell biology Signal transduction Binding protein G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Chimpanzee, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 124kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RANBP17 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Function:
May function as a nuclear transport receptor.
Subcellular Location:
Cytoplasm. Nucleus. Nucleus > nuclear pore complex.
Tissue Specificity:
Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.
Similarity:
Belongs to the exportin family.
Database links:Entrez Gene: 739299 Chimpanzee
Entrez Gene: 64901 Human
Omim: 606141 Human
SwissProt: Q9H2T7 Human
Unigene: 410810 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode