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Product Name Anti-RHCE/Biotin Chinese Name 生物素标记的Rh血型C抗原抗体 Alias Blood group Rh(CE) polypeptide; Blood group RhCcEe antigen; CD240CE; CD240CE antigen; RH; Rh blood group antigen Evans; Rh blood group C antigen; Rh blood group, CcEe antigens; Rh polypeptide 1; Rh polypeptide I; RH30A; Rh4; RHC; RHCE blood group variant Crawford antigen Rh43; RHE; Rhesus blood group CE protein; Rhesus blood group E antigen; Rhesus blood group Rhce antigen; Rhesus blood group, CcEe antigens; Rhesus C/E antigens; Rhesus system C and E polypeptides; RhIVb(J); RHIXB; RHPI; RhVI; RhVIII; RHCE_HUMAN. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 46kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RHCE Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. There are thirteen named isoforms.
Function:
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts.
Similarity:
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Database links:Entrez Gene: 6006 Human
Omim: 111700 Human
SwissProt: P18577 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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