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Product Name Anti-PRRG1/Biotin Chinese Name 生物素标记的跨膜γ羧基酸蛋白1抗体 Alias PRGP1; Proline rich gamma carboxyglutamic acid protein 1; Proline rich Gla (G carboxyglutamic acid) 1; Proline rich Gla (G carboxyglutamic acid) polypeptide 1; Proline rich Gla protein 1; Proline-rich gamma-carboxyglutamic acid protein 1; Proline-rich Gla protein 1; PRRG1; TMG1; TMG1_HUMAN; Transmembrane gamma carboxyglutamic acid protein 1 [Precursor]; Transmembrane gamma-carboxyglutamic acid protein 1. Research Area Tumour Cell biology immunology The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 23kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PRRG1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in the spinal cord.
Post-translational modifications:
Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
Similarity:
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Database links:
Entrez Gene: 5638 Human
Entrez Gene: 546336 Mouse
Omim: 604428 Human
SwissProt: O14668 Human
Unigene: 190341 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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