Product Name	Anti-TPMT/Biotin
Chinese Name	生物素标记的硫嘌呤甲基转移酶抗体
Alias	HGNC:12014; S adenosyl L methionine thiopurine S methyltransferase; Thiopurine methyltransferase; Thiopurine S methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMT_HUMAN.
Research Area	Tumour  Cell biology  immunology  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	28kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TPMT
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Subcellular Location: Cytoplasm. DISEASE: Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Similarity: Belongs to the methyltransferase superfamily. TPMT family. Database links: Entrez Gene: 7172 Human Entrez Gene: 22017 Mouse Entrez Gene: 690050 Rat Omim: 187680 Human SwissProt: P51580 Human SwissProt: O55060 Mouse SwissProt: Q9Z0T0 Rat Unigene: 444319 Human Unigene: 10169 Mouse Unigene: 112598 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TPMT是硫嘌呤类药物（如硫唑嘌呤、巯嘌呤和硫鸟嘌呤）的代谢中最主要的酶之一，起到的作用是在这类化合物的硫原子上增加一个甲基；这个过程中提供甲基的是S-腺苷甲硫氨酸，后者同时被转化成S-腺苷-L-高半胱氨酸。 TPMT基因的缺陷会让人体无法将这类药物灭活，未代谢的药物因此在体内大量累积，从而引起严重甚至致命的骨髓抑制，表现为贫血、血小板减少症（导致出血）和白细胞减少症（导致感染）等.

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