TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-GIRK2/Biotin Chinese Name 生物素标记的G蛋白激活内流钾Channel protein2抗体 Alias inwardly rectifying subfamily J member 6; Kir3.2; BIR1; G protein activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; GIRK-2; Inward rectifier K(+) channel Kir3.2; IRK6_HUMAN; KATP-2; Kcnj6; Kcnj7; Potassium channel; Potassium channel inwardly rectifying subfamily J member 6. Research Area Cell biology immunology Neurobiology Channel protein Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 47kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GIRK2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Function:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subunit:
Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
Database links:Entrez Gene: 3763 Human
Entrez Gene: 16522 Mouse
Omim: 600877 Human
SwissProt: P48051 Human
SwissProt: P48542 Mouse
Unigene: 626242 Human
Unigene: 658533 Human
Unigene: 741904 Human
Unigene: 328720 Mouse
Unigene: 10185 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode