Product Name	Anti-Claudin 9/AP
Chinese Name	碱性磷酸酶（AP）标记的紧密连接蛋白9抗体
Alias	Claudin-9; Claudin9; CLDN9; CLD9_HUMAN
Research Area	Cell biology  immunology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	23kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Claudin 9
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010] Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). May act as a coreceptor for HCV entry into hepatic cells. Subcellular Location: Cell junction; Cell membrane, Multi-pass membrane protein; Tissue Specificity: Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. Similarity: Belongs to the claudin family. Database links: Entrez Gene: 9080 Human Entrez Gene: 56863 Mouse Entrez Gene: 287099 Rat Omim: 615799 Human SwissProt: O95484 Human SwissProt: Q9Z0S7 Mouse Unigene: 296949 Human Unigene: 491368 Mouse Unigene: 113196 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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