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Rabbit Anti-GRINA/AP Conjugated antibody
Rabbit Anti-GRINA/AP Conjugated antibody
Glutamate [NMDA] receptor associated protein 1; Glutamate receptor, ionotropic, N methyl D aspartate associated protein 1 (glutamate binding); Glutamate receptor, NMDA subtype, glutamate binding subunit; HNRGW; LFG1; MGC99687; NMDA receptor glutamate bind
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  • NO.:SL20059R-AP
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)
    Applications:IHC-P IHC-F ICC
    concentration:1mg/ml
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Details

Product Name Anti-GRINA/AP
Chinese Name 碱性磷酸酶(AP)标记的谷氨酸受体相关蛋白1抗体
Alias Glutamate [NMDA] receptor associated protein 1; Glutamate receptor, ionotropic, N methyl D aspartate associated protein 1 (glutamate binding); Glutamate receptor, NMDA subtype, glutamate binding subunit; HNRGW; LFG1; MGC99687; NMDA receptor glutamate binding subunit; NMDARA1; Putative MAPK activating protein PM02; TMBIM3; Transmembrane BAX inhibitor motif containing 3; LFG1_HUMAN.  
Research Area Neurobiology  Channel protein  The cell membrane受体  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Cow, Rabbit, Sheep, )
Applications IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 41kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human GRINA
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, CREB function and gene regulation. As one of the four major proteins of the NMDA receptor ion channel, GRINA (Glutamate [NMDA] receptor-associated protein 1), also designated NMDA receptor glutamate-binding subunit or putative MAPK-activating protein PM02, is a 371 amino acid multi-pass transmembrane protein. Due to the chromosomal location of the gene encoding GRINA, studies have linked possible GRINA involvement with a form of idiopathic generalized epilepsy.

Function:
Potential apoptotic regulator.

Subcellular Location:
Membrane; Multi-pass membrane protein (potential).

Similarity:
Belongs to the BI1 family. LFG subfamily.

Database links:

Entrez Gene: 2907 Human

Omim: 138251 Human

SwissProt: Q7Z429 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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