Product Name	Anti-CBY1/AP
Chinese Name	碱性磷酸酶（AP）标记的富含亮氨酸胞浆蛋白CBY1抗体
Alias	PGEA1; CBY1; C22orf2; CBY; Cytosolic leucine rich protein; HRIHFB2025; PIGEA 14; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; Protein Chibby.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Stem cells  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	14kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CBY1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Subunit: Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin. Subcellular Location: Nucleus speckle. Golgi apparatus, trans Golgi network. Note: Nuclear, in a punctate manner. Also found in the trans Golgi. DISEASE: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. Similarity: Belongs to the chibby family. Database links: Entrez Gene: 25776 Human SwissProt: Q9Y3M2 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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