Product Name	Anti-Myelin expression factor 2/AP
Chinese Name	碱性磷酸酶（AP）标记的髓鞘表达因子2抗体
Alias	MYEF2; KIAA1341; MEF 2; MST156; MYEF2_HUMAN; MYEF 2; Myelin expression factor 2.
Research Area	immunology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	64kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Myelin expression factor 2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Product Detail	background: Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is responsible for adhesion of these surfaces in multilayered Myelin sheaths. As a member of a larger family of proteins with many forms and post-translational modifications, MBP appears to have several other functions as a result of these modifications, including participating in the transmission of extracellular signals, as well as cell signaling. These modifications of MBP are dynamic during normal central nervous system (CNS) development and during Myelin degeneration in multiple sclerosis (MS). Regulation of the human MBP gene occurs at the MB1 regulatory motif located between nucleotides -14 to -50. The MB1 element contains binding sites for both the activator protein MEF-1/Pur?and the repressor protein MYEF2. MYEF2 is a nuclear protein whose expression is developmentally regulated in mouse brain with peak expression occurring at postnatal day 7. Four isoforms of MYEF2 exist due to alternative splicing events. Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. Subunit: Monomer (By similarity). Subcellular Location: Nuclear Similarity: Contains 3 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 50804 Human Entrez Gene: 17876 Mouse SwissProt: Q9P2K5 Human SwissProt: Q8C854 Mouse Unigene: 6638 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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