Product Name	Anti-MARVELD2/AP
Chinese Name	碱性磷酸酶（AP）标记的MARVEL蛋白家族D2抗体
Alias	DFNB49; FLJ30532; MARVD2; MARVEL (membrane associating) domain containing 2; MARVEL domain containing 2; MARVEL domain containing protein 2; MARVELD 2; MARVELD2; MRVLDC2; Tric; Tricellulin.
Research Area	Cell biology  Signal transduction  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Monkey, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat)
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	64kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MARVELD2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, tight junction. Note=Found at tricellular contacts. DISEASE: Deafness, autosomal recessive, 49 (DFNB49) [MIM:610153]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note: The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 MARVEL domain. Database links: Entrez Gene: 461831 Chimpanzee Entrez Gene: 101128096 Gorilla Entrez Gene: 153562 Human Entrez Gene: 100173144 Orangutan Entrez Gene: 100516404 Pig Entrez Gene: 365657 Rat Omim: 610572 Human SwissProt: Q8N4S9 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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