Product Name	Anti-MON2/AP
Chinese Name	碱性磷酸酶（AP）标记的MON2蛋白抗体
Alias	mon2; MON2_HUMAN; Protein MON2 homolog; Protein SF21; SF21.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	190kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MON2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: MON2 is a 1,718 amino acid protein that exists as multiple alternatively spliced isoforms and plays an important role in membrane trafficking. Related to the guanine nucleotide exchange factors (GEFs), MON2 shares significant homology with BIG as well as the GBF (Golgi brefeldin A resistance factor) subfamilies of proteins. MON2 acts as a scaffold protein when associated with Dopey-1, a large cytoplasmic protein involved in trafficking between the late golgi and early endosomes. MON2 is homologous to the yeast protein and is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. Function: May be required for traffic between late Golgi and early endosomes. Similarity: Belongs to the MON2 family. Database links: Entrez Gene: 23041 Human Entrez Gene: 314894 Rat SwissProt: Q7Z3U7 Human Unigene: 389378 Human Unigene: 154642 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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