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Product Name Anti-SPOCK3/AP Chinese Name 碱性磷酸酶(AP)标记的富含半胱氨酸酸性分泌/骨粘连蛋白多糖抗体 Alias HSAJ1454; OTTHUMP00000219853; OTTHUMP00000219854; OTTHUMP00000219857; OTTHUMP00000219858; OTTHUMP00000219862; OTTHUMP00000219864; OTTHUMP00000219865; OTTHUMP00000219866; OTTHUMP00000219867; OTTHUMP00000219868; Sparc/osteonectin, cwcv and kazal like domains proteoglycan (testican) 3; SPARC/osteonectin, CWCV, and Kazal like domains proteoglycan 3; TES 3; testican 3; TICN3 Research Area Tumour Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 49kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SPOCK3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Function:
SPOCK3 may participate in diverse steps of neurogenesis. It inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP and may also interfere with tumor invasion.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Similarity:
Contains 1 Kazal-like domain. Contains 1 thyroglobulin type-1 domain.
Database links:Entrez Gene: 50859 Human
Entrez Gene: 72902 Mouse
Omim: 607989 Human
SwissProt: Q9BQ16 Human
SwissProt: Q8BKV0 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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