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Rabbit Anti-IRF2BP2/AP Conjugated antibody
Rabbit Anti-IRF2BP2/AP Conjugated antibody
I2BP2_HUMAN; Interferon regulatory factor 2 binding protein 2; Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; IRF-2BP2; IRF2 binding protein 2; IRF2BP2.
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  • NO.:SL16701R-AP
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,(predicted: Cow,Horse,Rabbit,)
    Applications:WB IHC-P IHC-F ICC
    concentration:1mg/ml
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Product Name Anti-IRF2BP2/AP
Chinese Name 碱性磷酸酶(AP)标记的Interferon调节因子2Binding protein2抗体
Alias I2BP2_HUMAN; Interferon regulatory factor 2 binding protein 2; Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; IRF-2BP2; IRF2 binding protein 2; IRF2BP2.  
Research Area transcriptional regulatory factor  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human,  (predicted: Cow, Horse, Rabbit, )
Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 61kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IRF2BP2
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Function:
Acts as a transcriptional repressor. Acts as a transcriptional corepressor in a IRF2-dependent manner. This repression is not mediated at least in part by histone deacetylase activities.

Subunit:
Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylation at Ser-360 is required for nuclear targeting.

Similarity:
Belongs to the IRF2BP family.

Database links:

Entrez Gene: 359948 Human

Entrez Gene: 270110 Mouse

Omim: 615332 Human

SwissProt: Q7Z5L9 Human

SwissProt: E9Q1P8 Mouse

Unigene: 350268 Human

Unigene: 491125 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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