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Product Name Anti-GTPBP4/AP Chinese Name 碱性磷酸酶(AP)标记的G蛋白Binding protein4/慢性肾功能衰竭蛋白抗体 Alias Chronic renal failure gene protein; CRFG; G protein binding protein CRFG; GTP binding protein 4; GTP-binding protein NGB; Gtpbp4; NGB; NOG1; NOG1_HUMAN; Nucleolar GTP binding protein 1; Nucleolar GTP-binding protein 1. Research Area Tumour Cell biology Signal transduction TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 74kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GTPBP4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Location:
Nucleus; nucleolus.
Similarity:
Belongs to the GTP1/OBG family. NOG subfamily.
Database links:Entrez Gene: 23560 Human
Entrez Gene: 69237 Mouse
SwissProt: Q9BZE4 Human
SwissProt: Q99ME9 Mouse
Unigene: 215766 Human
Unigene: 41800 Mouse
Unigene: 96111 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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