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Product Name Anti-EPB41L5/AP Chinese Name 碱性磷酸酶(AP)标记的红The cell membrane蛋白条带EPB41L5抗体 Alias Band 4.1-like protein 5; BE37; E41L5_HUMAN; Epb41l5; erythrocyte membrane protein band 4.1 like 5; KIAA1548. Research Area Cell biology Cell Surface Molecule Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 82kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human EPB41L5 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. EPB41L5 (erythrocyte membrane protein band 4.1 like 5), also known as BE37 or YMO1, is a 733 amino acid cytoplasmic protein that contains one FERM domain, which it uses to bind CRB1 (crumbs homolog 1). EPB41L5 is a homolog of zebrafish 'mosaic eyes' (moe), and is widely expressed but found at highest levels in ovary, kidney and brain, and is known to colocalize with β-catenin. EPB41L5 may participate in tight junction positioning during the establishment of epithelial cell polarity, and exists as four alternatively spliced isoforms that are encoded by a gene located on human chromosome 2q14.2.
Function:
May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Location:
Cytoplasm. Cell junction > adherens junction. Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker.
Similarity:
Contains 1 FERM domain.
Database links:Entrez Gene: 57669 Human
Omim: 611730 Human
SwissProt: Q9HCM4 Human
Unigene: 369232 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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