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Product Name Anti-GPRASP2/AP Chinese Name 碱性磷酸酶(AP)标记的G protein-coupled receptorGPRSP2蛋白抗体 Alias FLJ35662; FLJ37327; G-protein coupled receptor-associated sorting protein 2; GASP-2; GASP2; GPRASP2; GASP2_HUMAN. Research Area Cell biology immunology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 94kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPRASP2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
G protein-coupled receptors play a role in many different stimulus-response pathways. G protein-coupled receptors mediate extracellular signals into intracellular signals (G protein activation). They respond to a wide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GASP-2 (G protein-coupled receptor associated sorting protein 2), also known as GPRASP2, is an 838 amino acid protein that regulates a number of G-protein coupled receptors, such as CT-R (calcitonin receptor) and mAChR M1 (muscarinic acetylcholine receptor M1), through interactions with their cytoplasmic tails. Expressed primarily in brain, GASP-2 is a member of the GPRASP family and forms a complex with Huntingtin, with which it is thought to influence receptor trafficking.
Function:
May play a role in regulation of a variety of G-protein coupled receptors.
Subunit:
Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Expressed in the brain.
Similarity:
Belongs to the GPRASP family.
Database links:Entrez Gene: 114928 Human
Entrez Gene: 245607 Mouse
GenBank: NP_001004051 Human
SwissProt: Q96D09 Human
SwissProt: Q8BUY8 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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