Product Name	Anti-Chromogranin A/AP
Chinese Name	碱性磷酸酶（AP）标记的嗜铬粒素A抗体
Alias	beta Granin; CGA; CHG A; CHGA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin; ER-37; CMGA_HUMAN.
Research Area	Tumour
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	48kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CGA
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]. Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. Subunit: Interacts with SCG3. Subcellular Location: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. Post-translational modifications: Sulfated on tyrosine residues and/or contains sulfated glycans. O-glycosylated with core 1 or possibly core 8 glycans. Similarity: Belongs to the chromogranin/secretogranin proteinfamily. Database links: Entrez Gene: 1113 Human Entrez Gene: 12652 Mouse Omim: 118910 Human SwissProt: P10645 Human SwissProt: P26339 Mouse Unigene: 150793 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 嗜铬粒素A蛋白存在与很多组织中：胃肠道内分泌细胞和类癌、甲状旁腺、垂体前叶、肾上腺髓质、神经节、副神经节、胰岛、甲状腺C细胞等组织和其来源的Tumour都表达该成分.嗜铬素A（CgA）属于可溶性的酸性蛋白，主要存在于神经内分泌细胞的分泌颗粒中，也存在于含有分泌颗粒的内分泌细胞和神经内分泌细胞来源的Tumour细胞中。检测循环中的免疫反应CgA对神经内分泌瘤具有诊断意义。另外，CgA的免疫组织化学检测对鉴定来源于神经内分泌的Tumour起到辅助作用。

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