Product Name	Anti-IFITM1/AP
Chinese Name	碱性磷酸酶（AP）标记的Interferon诱导Transmembrane protein1抗体
Alias	CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu 13 antigen; Leu-13 antigen; LEU13; IFM1_HUMAN; Dispanin subfamily A member 2a; DSPA2a.
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	11.7kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IFITM1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. Function: IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. Similarity: Belongs to the CD225 family. Database links: Entrez Gene: 8519 Human Entrez Gene: 68713 Mouse Entrez Gene: 293618 Rat Omim: 604456 Human SwissProt: P13164 Human SwissProt: Q9D103 Mouse Unigene: 458414 Human Unigene: 175661 Mouse Unigene: 22087 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IFITM1蛋白是蛋白复合物的组分之一,主要功能是参与同型粘附和抗增殖信号的转导,与细胞增殖、Tumour分化、抗病毒、免疫监视等有关。IFITM-1主要用于消化系统Tumour方面的研究，有学者认为：Interferon诱导Transmembrane protein1与Interferon结合，可以抑制Tumour细胞的分化和增值。

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