Product Name	Anti-Neurogenin 3/AP
Chinese Name	碱性磷酸酶（AP）标记的神经元素3抗体
Alias	NGN3; neurogenin 3; Neurog3; Neurogenin3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5.
Research Area	Cell biology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Cow, Sheep, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	23kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NGN3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Function: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Subcellular Location: Nucleus. DISEASE: Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 50674 Human Entrez Gene: 11925 Mouse Entrez Gene: 60329 Rat Omim: 604882 Human SwissProt: Q9Y4Z2 Human SwissProt: P70661 Mouse Unigene: 532682 Human Unigene: 57236 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Neurobiology相关蛋白（Neurobiology） Ngn3属于bHLH家族蛋白，是胰腺发育过程中短暂表达的蛋白，可能是胰腺内分泌细胞系的定向因子，一般在成熟胰岛中不存在。 Ngn3的表达会导致胰腺内分泌细胞数的增加外分泌细胞数的减少。因而胰岛β细胞并不是完全靠Stem cells分化产生，主要是通过已分化胰岛β细胞的分裂增殖。 但近年来，有学者认为：Ngn3虽在胰腺发育中短暂表达，但是否存在使胰岛Stem cells或前体细胞自我更新的能力尚未明确定论。

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