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Product Name Anti-Connexin-36/AP Chinese Name 碱性磷酸酶(AP)标记的间隙连接蛋白36抗体 Alias Connexin 36; CX36; Gap junction protein alpha 9; gap junction protein, alpha 9, 36kDa; GJA9; MGC138315; MGC138319; CXD2_HUMAN. Research Area Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ) Applications WB=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 36kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Connexin-36 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion. [provided by RefSeq, Oct 2012]
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit:
A connexon is composed of a hexamer of connexins.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Tissue Specificity:
Highly expressed in neurons.
Similarity:
Highly expressed in neurons.
Belongs to the connexin family. Delta-type subfamily.
Database links:Entrez Gene: 395273 Chicken
Entrez Gene: 57369 Human
Entrez Gene: 14617 Mouse
Entrez Gene: 378444 Zebrafish
Omim: 607058 Human
SwissProt: Q9UKL4 Human
SwissProt: O54851 Mouse
SwissProt: Q6PDP3 Mouse
Unigene: 283816 Human
Unigene: 389394 Mouse
Unigene: 9904 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
间隙连接是神经系统构成电突触的结构基础,参与调控神经冲动纤毫传递和复杂神经网络的整合,而Cx36是唯一一个在神经系统中优先表达的Cx,因此成为电生理研究主要蛋白。
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