Product Name	Anti-TNFAIP1/AP
Chinese Name	碱性磷酸酶（AP）标记的Tumour坏死因子α诱导蛋白1抗体
Alias	tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial); BACD2_HUMAN; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; endothelial; hBACURD2; Protein B12; tnfaip1; Tumor necrosis factor alpha induced protein 1; TNF-IP 1; TNF-IP-1; TNF-IP1.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	35kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TNFAIP1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Subcellular Location: Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes. Post-translational modifications: Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. Similarity: Belongs to the BACURD family. Contains 1 BTB (POZ) domain. Database links: Entrez Gene: 7126 Human Entrez Gene: 21927 Mouse Entrez Gene: 287543 Rat Omim: 191161 Human SwissProt: Q13829 Human SwissProt: O70479 Mouse SwissProt: Q7TNY1 Rat Unigene: 76090 Human Unigene: 386774 Mouse Unigene: 18199 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TNFAIP1 protein是第一个被鉴定受Tumour坏死因子α诱导的蛋白,实验证明TNFAIP1 蛋白可能参与DNA复制、合成、Apoptosis以及人类的各种疾病等重要生理过程，但还有一些功能不清。

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