Product Name	Anti-srGAP3/AP
Chinese Name	碱性磷酸酶（AP）标记的精神障碍相关GAP蛋白抗体
Alias	ARHGAP 14; ARHGAP14; Gbi; ME GAP; MEGAP; Mental disorder associated GAP; Rho GTPase activating protein 14; SLIT ROBO Rho GTPase activating protein 3; srGAP 2; srGAP 3; srGAP2; SRGP 2; SRGP2; WAVE associated Rac GTPase activating protein; WRP.
Research Area	immunology  Neurobiology  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	121kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human srGAP3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: srGAP3 (SLIT ROBO Rho GTPase-activating protein 3) is a GTPase activating protein (GAP) for the small G protein Rac. It has a putative role in attenuating Rac1 signalling in neurons. srGAP3 is thought to act downstream of the Slit-Robo pathway, which regulates neuronal migration and axonal branching, and play an important role in axonal regeneration after axotomy. It also plays a putative role in severe mental retardation. Subunit: Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG. Tissue Specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. Database links: Entrez Gene: 9901 Human Entrez Gene: 259302 Mouse Entrez Gene: 500287 Rat Omim: 606525 Human SwissProt: O43295 Human SwissProt: Q812A2 Mouse Unigene: 654743 Human Unigene: 236401 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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