Product Name	Anti-ELMO1/AP
Chinese Name	碱性磷酸酶（AP）标记的吞噬细胞运动蛋白1抗体
Alias	CED 12; Ced 12 homolog 1; Ced 12 homolog; CED12; Ced12 homolog 1; Ced12 homolog; ELMO 1; Engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; ELMO1_HUMAN.
Research Area	Tumour  Cell biology  immunology  Apoptosis  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	84kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ELMO.
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: ELMO1 is involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. ELMO1 acts in association with DOCK1 and CRK and was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. It is belived to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Subunit: Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Subcellular Location: Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. Tissue Specificity: Widely expressed, with a higher expression in the spleen and placenta. Post-translational modifications: Phosphorylated by HCK (Probable). Similarity: Contains 1 ELMO domain. Contains 1 PH domain. Database links: Entrez Gene: 9844 Human Entrez Gene: 140580 Mouse Entrez Gene: 361251 Rat Omim: 606420 Human SwissProt: Q92556 Human SwissProt: Q8BPU7 Mouse Unigene: 656638 Human Unigene: 342392 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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