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Rabbit Anti-Sertad1/AP Conjugated antibody
Rabbit Anti-Sertad1/AP Conjugated antibody
CDK 4 binding protein p34SEI1; CDK4 binding protein p34SEI; CDK4 binding protein p34SEI1; SEI 1; SEI1; SERTA domain containing 1; SERTA domain containing 1 variant; SERTA domain containing protein 1; Sertad 1; Transcriptional regulator interacting with th
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  • NO.:SL6691R-AP
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Rabbit,)
    Applications:WB IHC-P IHC-F
    concentration:1mg/ml
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Details

Product Name Anti-Sertad1/AP
Chinese Name 碱性磷酸酶(AP)标记的调控周期蛋白依赖蛋白激酶SEI1抗体
Alias CDK 4 binding protein p34SEI1; CDK4 binding protein p34SEI; CDK4 binding protein p34SEI1; SEI 1; SEI1; SERTA domain containing 1; SERTA domain containing 1 variant; SERTA domain containing protein 1; Sertad 1; Transcriptional regulator interacting with the PHD bromodomain 1; TRIP Br1; SRTD1_HUMAN.  
Research Area Signal transduction  transcriptional regulatory factor  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, )
Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 25kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human SEI1 (1-35aa)
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Sertad1 acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).

Function:
Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).

Subunit:
Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4.

Similarity:
Contains 1 SERTA domain.

Database links:
 

UniProtKB/Swiss-Prot: Q9UHV2.2



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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