TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-NHEDC2/AP Chinese Name 碱性磷酸酶(AP)标记的Mitochondrion钠/氢Exchange protein质2抗体 Alias NHA2; Mitochondrial Na(+)/H(+) exchanger NHA2; Mitochondrial sodium/hydrogen exchanger NHA2; Na(+)/H(+) exchanger like domain containing protein 2; Na+/H+ exchanger domain containing 2; NHE domain containing protein 2; NHE10; NHEDC 2; Sodium/hydrogen exchanger like domain containing protein 2; SL9B2_HUMAN. Research Area Cell biology Signal transduction Cyclin Cell differentiation Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Rabbit, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 58kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NHEDC2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.
Function:
Electroneutral exchange of protons for Na(+) and Li(+)across the inner mitochondrial membrane. Contributes to theorganellar volume homeostasis. Required for osteoclastdifferentiation and bone resorption activity (By similarity).
Subcellular Location:
Mitochondrion membrane; Multi-pass membraneprotein (By similarity).
Tissue Specificity:
Detected in red blood cells (at proteinlevel).
Similarity:
Belongs to the monovalent cation:proton antiporter 1(CPA1) transporter (TC 2.A.36) family.
Database links:Entrez Gene: 133308 Human
Entrez Gene: 97086 Mouse
Omim: 611789 Human
SwissProt: Q86UD5 Human
SwissProt: Q5BKR2 Mouse
Unigene: 546482 Human
Unigene: 441764 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode