Product Name	Anti-Orai2/AP
Chinese Name	碱性磷酸酶（AP）标记的Transmembrane proteinOrai2抗体
Alias	C7orf19; CAP binding protein complex interacting protein 2; CBCIP 2; CBCIP2; Chromosome 7 open reading frame 19; FLJ12474; FLJ14733; FLJ44818; H_NH0514P08.8; Orai 2; ORAI calcium release activated calcium modulator 2; Protein orai 2; TMEM 142B; TMEM142B; Transmembrane protein 142B.
Research Area	Cell biology  immunology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	29kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Orai2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1. Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Subunit: Interacts with EFCAB4B/CRACR2A. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the Orai family. Database links: Entrez Gene: 80228 Human Entrez Gene: 269717 Mouse Entrez Gene: 304592 Rat Omim: 610929 Human SwissProt: Q96SN7 Human SwissProt: Q8BH10 Mouse Unigene: 363308 Human Unigene: 308396 Mouse Unigene: 18207 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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