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Rabbit Anti-PNRC2/APC Conjugated antibody
Rabbit Anti-PNRC2/APC Conjugated antibody
0610011E17Rik; D4Bwg0593e; FLJ20312; MGC11707; MGC93828; MGC99541; OTTMUSP00000010360; OTTMUSP00000010366; pnrc2; PNRC2_HUMAN; Proline rich nuclear receptor coactivator 2; Proline-rich nuclear receptor coactivator 2; RP11-4M23.5; RP23-161N17.3.
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  • NO.:SL12748R-APC
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,Rat,(predicted: Human,)
    Applications:ICC IF
    concentration:1mg/ml
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Product Name Anti-PNRC2/APC
Chinese Name APC标记的富含脯氨酸核受体共激活因子2抗体
Alias 0610011E17Rik; D4Bwg0593e; FLJ20312; MGC11707; MGC93828; MGC99541; OTTMUSP00000010360; OTTMUSP00000010366; pnrc2; PNRC2_HUMAN; Proline rich nuclear receptor coactivator 2; Proline-rich nuclear receptor coactivator 2; RP11-4M23.5; RP23-161N17.3.  
Research Area Cell biology  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse, Rat,  (predicted: Human, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 16kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human PNRC2
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail Function:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.

Subcellular Location:
Nucleus. Cytoplasm > P-body.

Tissue Specificity:
Expressed in heart, lung, muscle and brain.

Similarity:
Belongs to the PNRC family. PNRC2 subfamily.

Database links:

Entrez Gene: 100505603 Human

Entrez Gene: 55629 Human

Entrez Gene: 52830 Mouse

Entrez Gene: 100125373 Rat

Omim: 611882 Human

SwissProt: Q9NPJ4 Human

SwissProt: Q9CR73 Mouse

SwissProt: Q66HE1 Rat

Unigene: 512636 Human

Unigene: 644217 Human

Unigene: 716935 Human

Unigene: 7862 Human

Unigene: 29159 Mouse

Unigene: 118788 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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